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Lion's Mane Extended / Yamabushitake

Hericium erinaceus (NGF strain)

Neuroprotectivemoderate evidence

Hericenones and erinacines from Lion's Mane are the only known natural compounds that stimulate Nerve Growth Factor (NGF) synthesis — offering real potential to reverse chemotherapy-induced peripheral neuropathy (CIPN) and 'chemo brain'. Clinical studies confirm cognitive improvements in humans. Anti-cancer activity documented against gastric, colon, and liver cancers.

Medicinal Properties

NeuroprotectiveNGF stimulatingAnti-tumourCognitive enhancerImmunomodulatory

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Cancer Types Studied

GastricColonLiver

Recommended Dosage

1000–3000 mg standardised Lion's Mane extract (30% beta-glucan) daily.

Preparations

High-beta-glucan Extract

1000–3000 mg Lion's Mane extract standardised to 30% beta-glucan daily. Use dual-extract (hot water + alcohol extraction) for maximum hericenones.

NIH / PubMed Research

PMID 23735479Lion's Mane hericenones NGF and cognitive function

Links open on PubMed (National Library of Medicine). Research is ongoing — results may not reflect clinical use.

Cautions & Interactions

Generally very safe
May cause mild digestive upset initially
Potential allergy in mushroom-allergic individuals
Choose dual-extracted products — single water extraction misses important hericenones